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Models

Tumor Targets

Humanized tumor target mice are immunocompetent chimeric mouse models, engineered to express humanized tumor targets such as genes encoding for oncogene proteins, tumor suppressor proteins, tumor specific antigen, etc. These models can can be used to evaluate the risk of on-target, off-tumor toxicities for targeted cancer drug.

mouse
R26-CAG-LSL-hPLAG1-IRES-Luc-2A-tdTomato
Strain Name：C57BL/6JSmo-Gt(ROSA)26Sortm1(CAG-LSL-hPLAG1-IRES-Luciferase-2A-tdTomato-wpre-polyA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-215002
mouse
R26-CAG-LSL-hREST-IRES-tdTomato
Strain Name：C57BL/6JSmo-Gt(ROSA)26Sortm1(CAG-LSL-REST-IRES-tdTomato-WPRE-polyA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-200051
Research Application：Cancer and aging research
mouse
R26-CAG-LSL-hREST4-IRES-EGFP
Strain Name：C57BL/6JSmo-Gt(ROSA)26Sortm1(CAG-LSL-REST4-IRES-EGFP-WPRE-polyA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200052
mouse
R26-CAG-LSL-hRHOA*Y42C-IRES-tdTomato
Strain Name：C57BL/6JSmo-Gt(ROSA)26Sortm1(SA-FRT-2xpolyA-CAG-FRT-LSL-RHOA(Y42C)-IRES-tdTomato-WPRE-polyA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-200048
Research Application：Cancer research
mouse
R26-CAG-LSL-hSOS-F-tdTomato
Strain Name：C57BL/6JSmo-Gt(ROSA)26Sortm1(SA-FRT-2xpolyA-CAG-FRT-loxp-Stop-loxp-SOS-F-IRES-tdTomato-WPRE-PA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-200020
Research Application：Spontaneous skin cancer model
mouse
R26-CAG-LSL-hSOX2-IRES-Luc-2A-EGFP/Kras-LSL-G12D
Strain Name：C57BL/6JSmo-Gt(ROSA)26Sortm(CAG-LSL-SOX2-IRES-Luciferase-2a-EGFP-WPRE-polyA)Krasem4(LSL-G12D)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-234153
mouse
R26-CAG-LSL-hTPM3-NTRK1-IRES-Luc-2A-tdTomato
Strain Name：C57BL/6JSmo-Gt(ROSA)26Sortm(SA-polyA-CAG-LSL-TPM3-NTRK1-IRES-luc-2A-tdTomato-WPRE-polyA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-190098
Research Application：Colorectal carcinoma related.
mouse
R26-CAG-LSL-hWNT1
Strain Name：C57BL/6JSmo-Gt(ROSA)26Sorem1(SA-FRT-2xpA-CAG-FRT-loxp-STOP-loxp-WNT1-IRES-Luciferase-2A-tdTomato-WPRE-polyA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-190128
Research Application：Wnt1 signaling pathway, cancer research, etc
mouse
R26-CAG-LSL-SOX2-IRES-Luc-2A-EGFP
Strain Name：C57BL/6JSmo-Gt(ROSA)26Sorem(CAG-LSL-SOX2-IRES-Luciferase-2a-EGFP-WPRE-polyA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-210138
Research Application：Fluorescent reporter Mice
mouse
R26-hCD46-IRES-tdTomato
Strain Name：C57BL/6JSmo-Gt(ROSA)26Sortm1(SA-hCD46-IRES-tdTomato-polyA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-190087
Research Application：Immune-related
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