Syngeneic Models

Syngeneic models are the xenograft tumor model formed by implanting tumour cell lines derived from the same background into immunocompetent inbred mice (typically C57BL/6 or BALB/c mice).
Syngeneic models have a healthy immune system that can be used in researching tumour Immunotherapy, usually being applied in efficacy research that needs a full immune system.

Mouse-derived cell lines

原代细胞系
Original cell lines
靶点人源化鼠源细胞系
Target humanized mouse-derived cell lines

Immunocompetent mice

靶点人源化小鼠
Target humanized mouse
野生型小鼠
wild-type mouse

Case Studies

Construction and efficacy evaluation in subcutaneous colorectal cancer xenograft model

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Fig. In vivo efficacy of anti-PD-1/CTLA-4 antibody drugs in inhibiting MC38 and CT26 colorectal cancer xenografts. 

Construction and efficacy evaluation in malignant pleural effusion model

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Fig. Mouse Lewis lung cancer pleural effusion model constructed by in situ injection of LLC-Luc cell line. a. Efficacy tumourigenic curve; b. Efficacy body weight curve; c. Survival rate of mice; d. Photographs of lungs, tumours, and pleural effusions in mice.


Efficacy evaluation of ADC drug in hPD-1 mice of colorectal cancer

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Fig. In vivo efficacy of ADC drugs targeting NECTN4 to inhibit the progression of MC38-NECTIN4 homologous tumour cells (host is hPD-1 mice on C57BL6 background)


Efficacy evaluation of antiboby in hTNFR2 mice

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Fig. Evaluation of antitumour efficacy in hTNFR2 humanised mice. a. Efficacy tumorigenic curve; b. Efficacy body weight curve.

Efficacy evaluation of bispecific antibody in hPD1/hCTLA4 mice

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Fig. Evaluation of antitumour efficacy in hPD1/hCTLA4 humanised mice. a. Efficacy tumourigenic curve; b. Efficacy body weight curve.

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