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Models

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Mice

NMG

Strain Name：NOD.Cg-PrkdcscidIl2rgem1Smoc
Strain State：Repository Live | Cat. NO.：NM-NSG-001

Prkdc and Il2rg genes were both knocked-out in NOD mice.  Lacking mature T, B and NK cells Low immune rejection against human cells and tissues Good tumorigenicity so that a small number of cells can form tumors. Significant improvement in the survival of transplanted human cells and tissues Suitable for the transplantation of human hematopoietic stem cells and the preparation of humanized mouse models Suitable as the carrier mice for the transplantation of heterologous cells and tissues

Mice

Rag1-KO(Rag1-EGFP)

Strain Name：B6;129S-Rag1tm1(loxP-EGFP-PolyA-loxP-Neo-loxP)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00069

A loxP-EGFP-PolyA-loxP-Neo-loxP expression cassette was knocked into the Rag1 gene start codon site. As a Rag1 knockout mouse model, this stain can be used in subcutaneous inoculation of liver cancer tissues and tumor cells. Tumors can esaily form and grow. The amount of T and B lymphocytes in peripheral blood of mice was extremely low tested by FACS, which was comparable to or lower than that of Nude mice, and there was a significant difference compared with wild type mice. The pathological sections of HE staining of tumor tissues showed that the tumor sections of Rag1 KO mice and Nude mice were similar. This strain has the potential to replace Nude, NOD-SCID mice as a tumor-bearing mouse model.

Mice

Alb-2A-DTRGFP(NMG)

Strain Name：NOD-Prkdcscid Il2rgem1Albem1(2A-DTRGFP)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-215047

2A-DTRGFP expression cassette was knocked into the Alb gene.

Mice

B2m-KO(NMG)

Strain Name：NOD.Cg-PrkdcscidIl2rgem1SmocB2mem1Smoc
Strain State：Repository Live | Cat. NO.：NM-NSG-002

This B2m knockout mouse model was obtained by knocking out the exon 2-3 region of mouse B2m gene on the background of NMG mouse.

Mice

hB2M-HLA A2.1(NMG,2)

Strain Name：NOD-PrkdcscidIl2rgem1B2mem1(hB2M-HLA A2.1)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-225090

The endogenous mouse B2m gene was replaced by human B2M-HLA A2.1 gene.

Mice

Csf1r-IRES-Cre

Strain Name：C57BL/6Smoc-Csf1rem3(IRES-iCre)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-190026

A IRES-iCre expression cassette was knocked into the Csf1r gene stop codon site.

Mice

hB2M-HLA A2.1(NMG)

Strain Name：NOD-PrkdcscidIl2rgem1H2-D1em1(hB2M-HLA A2.1)Smoc
Strain State：Developing | Cat. NO.：NM-HU-225089

The endogenous mouse H2-D1 gene was replaced by human B2M-HLA A2.1 gene.

Mice

mB2m-hFCRN(NMG)

Strain Name：NOD-PrkdcscidIl2rgem1Fcgrtem1(B2m-FCGRT)Smoc
Strain State：Repository Live | Cat. NO.：NM-NSG-018

A B2m-Linker-FCGRT-WPRE-polyA expression cassette was knocked into the Fcgrt gene exon3 of the NMG(NM-NSG-001) mice.

Mice

hEGFR

Strain Name：C57BL/6Smoc-Egfrtm1(hEGFR)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-200227

The endogenous mice Egfr gene was replaced by human EGFR gene. While hEGFR(2)(Stock No.NM-HU-200232) mice have been pulled from shelves for some reasons.

Mice

NVG-hIL15

Strain Name：NOD.Cg-PrkdcscidIl2rgem1SmocIl15em1(hIL15)Smoc
Strain State：Repository Live | Cat. NO.：GM-NVG-210001

The endogenous mice Il15 gene was replaced by human IL15 gene.

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