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Models

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Mice

h4-1BB(2)/hPD-1/hPD-L1

Strain Name：C57BL/6Smoc-Tnfrsf9tm2(TNFRSF9)Pdcd1em1(hPDCD1)Cd274em1(hPD-L1)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210357

h4-1BB(2)(NM-HU-190077), hPD-L1(NM-HU-00062) and hPD-1(NM-HU-00015) was crossed together to generate h4-1BB(2)/hPD-1/hPD-L1 mice.

Mice

H11-CAG-LSL-Myc

Strain Name：C57BL/6Smoc-Igs2em1(CAG-LSL-Myc)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00039

The c-Myc gene (also known as Myc) is abnormally expressed in many tumors and plays a critical role in the regulation of cell proliferation, growth and metabolism, gene instability, stimulation of angiogenesis, malignant transformation, cell differentiation and apoptosis. These mice harbor a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven Myc oncogene. The targeted mutation was inserted into the Hipp11(H11) locus by homologous recombination. Myc is expressed when bred to mice that express Cre recombinase.

Mice

hAXL

Strain Name：C57BL/6Smoc-Axltm1(hAXL)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-215067

The endogenous mouse Axl gene was replaced by human AXL gene.

Mice

hANGPTL3(4)

Strain Name：C57BL/6Smoc-Angptl3em1(hANGPTL3)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-210036

The endogenous mice Angptl3 gene was replaced by human ANGPTL3 gene. While hANGPTL3(Stock No.NM-HU-200113) have been pulled from shelves for some reasons and hANGPTL3(3)(Stock No.NM-HU-210037) mice function similarly to hANGPTL3(2) mice, for more detailed information please contact our technical advisor.

Mice

B2m-KO(NMG)

Strain Name：NOD.Cg-PrkdcscidIl2rgem1SmocB2mem1Smoc
Strain State：Repository Live | Cat. NO.：NM-NSG-002

This B2m knockout mouse model was obtained by knocking out the exon 2-3 region of mouse B2m gene on the background of NMG mouse.

Mice

Adgre1-2A-CreERT2

Strain Name：C57BL/6Smoc-Adgre1em1(2A-CreERT2)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-190025

A 2A-CreERT2 expression cassette was knocked into the Adgre1 gene stop codon site.

Mice

hAppNL-F

Strain Name：C57BL/6Smoc-Apptm3(hAppNL-F)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000087

The endogenous mouse App gene was replaced by human AppNL-F.

Mice

hCD38(2)

Strain Name：C57BL/6Smoc-Cd38em2(CD38)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190059

The endogenous mouse Cd38 gene was replaced by human CD38 gene. While hCD38 mice(Stock No.NM-HU-00113）have been pulled from shelves for some reasons.

Mice

hB2M-HLA A2.1(NMG,2)

Strain Name：NOD-PrkdcscidIl2rgem1B2mem1(hB2M-HLA A2.1)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-225090

The endogenous mouse B2m gene was replaced by human B2M-HLA A2.1 gene.

Mice

Foxp3-IRES-DTR-2A-tdTomato(BALB/c)

Strain Name：BALB/cAnSmoc-Foxp3em9(IRES-DTR-2A-tdTomato)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-200213

A IRES-DTR-2A-tdTomato expression cassette was knocked into the Foxp3 gene stop codon site.

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