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Models

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Mice

hANGPTL3(4)

Strain Name：C57BL/6Smoc-Angptl3em1(hANGPTL3)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-210036
Validation Data：有

The endogenous mice Angptl3 gene was replaced by human ANGPTL3 gene. While hANGPTL3(Stock No.NM-HU-200113) have been pulled from shelves for some reasons and hANGPTL3(3)(Stock No.NM-HU-210037) mice function similarly to hANGPTL3(2) mice, for more detailed information please contact our technical advisor.

Mice

Rag2-KO(Rag2-EGFP)

Strain Name：B6;129S-Rag2tm1(loxP-EGFP-PolyA-loxP-Neo-loxP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00070
Validation Data：有

A loxP-EGFP-PolyA-loxP-Neo-loxP expression cassette was knocked into the Rag2 gene start codon site. As a Rag2 knockout mouse model, this stain can be used in subcutaneous inoculation of liver cancer tissues and tumor cells. Tumors can esaily form and grow. The amount of T and B lymphocytes in peripheral blood of mice was extremely low tested by FACS, which was comparable to or lower than that of Nude mice, and there was a significant difference compared with wild type mice. The pathological sections of HE staining of tumor tissues showed that the tumor sections of Rag2 KO mice and Nude mice were similar. This strain has the potential to replace Nude, NOD-SCID mice as a tumor-bearing mouse model.

Mice

R26-CAG-LSL-tdTomato-2A-DTR

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem(CAG-LSL-R-tdTomato-2A-DTR)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-210094
Validation Data：有

These mice harbor a CAG-LSL-R-tdTomato-2A-DTR cassette in the Rosa26 locus generated by homologous recombination.

Mice

hCCL4

Strain Name：C57BL/6Smoc-Ccl4em1(hCCL4)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210013
Validation Data：有

The endogenous mice Ccl4 gene was replaced by human CCL4 gene

Mice

hCCR8(2)

Strain Name：C57BL/6Smoc-Ccr8em3(hCCR8)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000054
Validation Data：有

The endogenous mouse Ccr8 gene was replaced by human CCR8 gene. While hCCR8(Stock No.NM-HU-190053) mice function similarly to hCCR8(2) mice,for more detailed information please contact our technical advisor.

Mice

R26-CAG-LSL-Luc-tdTomato

Strain Name：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LSL-luci-2A-tdTomato)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-18051
Validation Data：有

A CAG-loxP STOP-loxP-luci-2A-tdTomato-WPRE-polyA cassette was knocked into the mouse ROSA26 locus . This strain of mice can be mated with mice expressing Cre recombinase so that luciferase and tdTomato fluorescent protein could be expressed for cell tracing.

Mice

hAQP4

Strain Name：C57BL/6Smoc-Aqp4em1(hAQP4)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210001
Validation Data：无

The endogenous mice Aqp4 gene was replaced by human AQP4 gene

Mice

h4-1BB(2)/hPD-1/hPD-L1

Strain Name：C57BL/6Smoc-Tnfrsf9tm2(TNFRSF9)Pdcd1em1(hPDCD1)Cd274em1(hPD-L1)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210357
Validation Data：无

h4-1BB(2)(NM-HU-190077), hPD-L1(NM-HU-00062) and hPD-1(NM-HU-00015) was crossed together to generate h4-1BB(2)/hPD-1/hPD-L1 mice.

Mice

hADORA2A

Strain Name：C57BL/6Smoc-Adora2aem1(hADORA2A)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-215061
Validation Data：有

The endogenous mouse Adora2a gene was replaced by human ADORA2A gene.

Mice

Rag1-KO(Rag1-EGFP)

Strain Name：B6;129S-Rag1tm1(loxP-EGFP-PolyA-loxP-Neo-loxP)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-00069
Validation Data：有

A loxP-EGFP-PolyA-loxP-Neo-loxP expression cassette was knocked into the Rag1 gene start codon site. As a Rag1 knockout mouse model, this stain can be used in subcutaneous inoculation of liver cancer tissues and tumor cells. Tumors can esaily form and grow. The amount of T and B lymphocytes in peripheral blood of mice was extremely low tested by FACS, which was comparable to or lower than that of Nude mice, and there was a significant difference compared with wild type mice. The pathological sections of HE staining of tumor tissues showed that the tumor sections of Rag1 KO mice and Nude mice were similar. This strain has the potential to replace Nude, NOD-SCID mice as a tumor-bearing mouse model.

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