Surgical & Preconditioning Services
Tumor models
● Subcutaneous model
● Metastatic model
● Orthotopic tumor model
● DEN-induced liver cancer model
● NSEE-induced gastric cancer model
Digestive System Disease Models
● Acute liver failure model
● 70% liver ischemia reperfusion injury (Liver IR)
● Surgery-induced liver fibrosis model
● Chemical drug-induced liver fibrosis model
● Liver regeneration
Urinary System Disease Models
● Chronic renal failure model
● Acute renal failure model
● Unilateral ureteral obstruction model
● Renal ischemia reperfusion injury model
Endocrine/Metabolic Disease Models
● Type I or type II diabetes mouse model
● Ovariectomy induced osteoporosis model
Inflammation & Immunological Disease Models
● Chemotherapy/Chemical-Induced enteritis model
● Psoriasis model
● Atopic dermatitis model
● Bone marrow transplant
● Experimental Autoimmune Encephalomyelitis (EAE) model
Nervous System Disease Models
● Parkinson's disease model
● Middle cerebral artery occlusion (MCAO) model
Cardiovascular System Disease Models
● Transverse aortic constriction (TAC) model
● Coronary artery ligation model
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Cre-ERT2在无Tamoxifen诱导的情况下，在细胞质内处于无活性状态；当Tamoxifen诱导后，Tamoxifen的代谢产物4-OHT（雌激素类似物）与ERT结合，可使Cre-ERT2进核发挥Cre重组酶活性。
Learn more你一定听说过Cre-lox重组系统，无论你是否直接进行过基因操作。由于Cre-lox系统具有操作简单、重组率高的优点，如今已经成为体内外遗传操作的强有力工具。利用Cre-lox系统，可以在特定细胞、组织或整个生物体，甚至在特定时间点敲除或表达某个基因，实现对特定基因的时空特异性操作，这对基因功能的研究和人类疾病动物模型的建立都具有深刻影响。
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