毒理/病理检测平台基因敲除小鼠_转基因小鼠定制-南模生物

Non-GLP toxicology studies are typically conducted in the early stages of drug discovery and for preliminary toxicological assessment. Their primary purpose is to explore the toxicological properties of new compounds, thereby providing guidance for subsequent study design and project decision-making.
The SMOC maintains an AAALAC-accredited SPF (specific pathogen-free) animal facility, equipped with comprehensive clinical laboratory equipment as well as histopathology and physiological testing instruments. We provide non‑GLP early toxicity evaluation services to generate adequate safety data for druggability assessment.

Services Project

Toxicokinetics tests
Acute toxicity tests (MTD)
Repeated dose toxicity tests
Carcinogenicity tests
Inflammatory factor storm

Case Studies

Evaluation of the toxicity of anti-human CD40 antibodies in hCD40 mice (comprehensive analysis of CBC, blood chemistry, cytokines, etc.)

Fig 1. Changes in tumor volume and weight during administration of anti-human CD40 antibody.

Fig 2: Complete blood count (CBC) in hCD40 mice following treatment with anti-human CD40 antibody.

Fig 3: Biochemical measurements in the blood of hCD40 mice treated with anti-human CD40 antibody

Fig 4: Cytokine analysis following treatment of hCD40 mice with anti-human CD40 antibody.

Cytokine analysis of MC38-tumor-bearing hCD40 mice treated with anti-human CD40 antibody revealed varying cytokine expression patterns. Treatment with anti-human CD40 antibody resulted in a significant increase in multiple cytokines, including IL-12 (p40) and eotaxin.

The SMOC Pathology Service Platform integrates a one-stop service capability from meticulous dissection of mice to digital histopathological analysis, covering H&E staining, immunofluorescence, immunohistochemistry, and a variety of histochemical staining techniques. We not only perform standard pathological testing procedures but also flexibly address unique experimental needs from clients, providing personalized, high-quality research support and services.

Services Project

Services Type	Project Name
Sampling	Routine Sampling (Mice and Rats)
Sampling	Specific Sampling (Mice and Rats)
Paraffin Sectioning	Dehydration and Paraffin Embedding
Paraffin Sectioning	Tissue Sectioning
Frozen Sectioning	Dehydration and OCT Embedding
	Frozen Sectioning
	Tissue Sectioning
Chemical Staining	H&E Staining
	Masson's Staining
	Oil Red O (Section) Staining
	PAS Staining
	Prussian Blue Staining
	LFB Staining
	Toluidine Blue Staining
	Alizarin Red Staining

Services Type	Project Name
IHC	Immunohistochemistry (IHC)
Immunofluorescence	DAPi Staining
	Tissue Immunofluorescence Experiment (Single Marker)
	Tissue Immunofluorescence Experiment (Double Marker)
	Tissue Immunofluorescence Experiment (Triple Marker)
Imaging	Tissue Whole-Mount Microscopy (Mice)
Panoramic Scanning	Standard Section Overview (Bright Field)
	Tissue Microarray Overview (Bright Field)
	Immunofluorescence Scanning Overview (Single Marker, Dual Color)
	Immunofluorescence Scanning Overview (Single Marker, Triple Color)
	Immunofluorescence Scanning Overview (Single Marker, Quadruple Color)
Analysis	H&E Staining Interpretation

Instruments and Equipment

Fluorescence microscopy of body postures

(SMZ18,Nikon)
Stereo Microscope

(SMZ800N,Nikon)
Paraffin sections machine

(RM2335,Leica)
Tissue embedding machine

(HistoCore Arcadia,Leica)
Frozen section machine

(CM1950,Leica)
Fully enclosed organization sample dehydrator

(HistoCore Pearl,Leica)
Immunohistochemistry and in situ hybridization staining machine

(BOND RX,Leica)
Panoramic Imaging System

(Aperio Versa8,Leica)