CDX is a model constructed by transplanting human tumor cells cultured in vitro into immunodeficient mice, containing benefits like short building time, good repeatability, and low cost. As a classic in vivo experimental method, CDX tumor model is in huge demand in oncology research and anti-tumor drug development.
CDX tumor model case studies
Fig. In situ transplantation tumor model based on HepG2-Luc hepatocellular carcinoma cells (host mouse: M-NSG). a. Model tumourigenic curve versus body weight curve; b. Photograph of mouse liver; c. Mouse live imaging image.
Fig. Lung in situ graft tumour model constructed based on the human SHP-77-Luc lung cancer cell line.
Fig. Pancreatic in situ graft tumour model constructed based on the human PANC-1-Luc pancreatic cancer cell line.
Fig. Cervical transplantation in situ tumour model constructed based on the human Hela-Luc cervical cancer cell line.
Fig. In situ graft tumour model of glioma constructed based on the human U87MG glioma cell line.
Fig. Renal graft-in-situ tumor model constructed based on the human 786-O renal cancer cell line.
Fig. In situ transplant tumour model of bladder cancer constructed based on the human RT112-Luc bladder cancer cell line.
Fig. Femoral injection bone metastasis model constructed based on the human MDA-MB-231-Luc breast cancer cell line.
CDX tumor Efficacy Case Studies
Fig. Anti-tumour drug efficacy validation experiments using the CDX model of ovarian cancer cell line (SK-OV-3).
Fig. CAR-T cell therapy efficacy validation experiment using lung cancer cell line (A549) CDX model.
Fig. mRNA anti-tumor drug efficacy validation experiments using the CDX model of the B-lymphoblastic leukaemia cell line (Nalm6-Luc).
PDX is a model constructed by transplanting tumor tissues from tumor patients into the bodies of severe immunodeficient mice. PDX model can relatively completely maintain the original biological characteristics, pathological typing, expression of molecular
markers, and types of genetic mutations of the patient's tumor.
SMOC can provide over 2000 PDX models such as lung cancer, liver cancer, cervical
cancer, colorectal cancer, brain tumors, prostate cancer, breast cancer, kidney cancer, stomach cancer, pancreatic cancer.
