Introduction
Intracranial tumors refer to neoplasms of the nervous system that occur within the cranial cavity, including primary tumors originating from neuroepithelial tissue, the meninges, germ cells, peripheral nerves, among others, as well as secondary tumors that metastasize to the brain from other systems. Orthotopic brain tumor models can recapitulate the growth environment and biological behavior of human brain tumors in vivo, and are used to study various aspects such as the mechanisms of brain tumor development and pharmacotherapy.
Disease models
The SMOC has been deeply engaged in the field of neuro-oncology research and has established a variety of intracranial tumor models, including glioblastoma and brain metastasis models. These models can be widely applied for elucidating tumor invasion mechanisms, developing targeted therapeutics, and optimizing combination treatment strategies.
The orthotopic tumor-bearing model is one of the commonly used models for studying the pathogenesis and therapeutic approaches of glioblastoma. This model typically employs stereotaxic injection technology to implant tumor cells into the hippocampal region of the brain of rats or nude mice. This method significantly reduces surgical mortality, increases the intracranial tumor formation rate, and is stable and reliable.
Fig1. Orthotopic transplantation tumor model of U87MG-Luc glioma cells.
