Introduction
Androgenetic alopecia (AGA) is a type of hair loss influenced by genetic factors and androgens, characterized by hair loss on the crown and forehead. Both males and females can be affected, but it is more common and pronounced in males. Androgenetic alopecia is characterized by progressive thinning of the hair, eventually leading to partial or complete baldness. Currently, various treatment options are available to help slow the progression of hair loss or promote hair regrowth, including pharmacotherapy, laser therapy, and hair transplantation.
Disease models
The SMOC has long been dedicated to research on autoimmune diseases and has developed a variety of mouse models of hair loss, providing powerful tools for the efficacy evaluation and safety assessment of related drugs.
After an acclimatization period of 7 days, the dorsal skin area of approximately 2 × 2 cm was depilated for all mice (Day 0).
Control group: Treated with saline; Model group: Treated with testosterone propionate; Treatment group: Treated with testosterone propionate + minoxidil tincture.
Fig.1 clinical symptoms of androgenetic alopecia mouse model and statistical data analysis, other analysis are on going.
Fig.2 Representative images of H&E pathological results. Blue arrow means normal hair follicle.
