Introduction
Sepsis is a condition in which, during infection or tissue injury, pathogen-associated molecular patterns (PAMPs) or damage-associated molecular patterns (DAMPs) activate the host immune system, leading to an imbalance between pro-inflammatory and anti-inflammatory responses, cytokine storm, and microcirculatory dysfunction. As sepsis progresses, it can result in multiple organ failure, refractory shock, and disseminated intravascular coagulation (DIC), clinically presenting as severe sepsis or septic shock.
Disease models
The SMOC has long been dedicated to autoimmune disease research and has developed a variety of sepsis mouse models using LPS induction, cecal ligation and puncture (CLP) induction, and other approaches, providing powerful tools for the efficacy evaluation and safety assessment of related drugs
