Dmd-Q995X
Nomenclature
C57BL/6JSmo-Dmdem1(Q995X)Smoc
Cat. NO.
NM-KI-18026
Strain State
Repository Live
Gene Summary
Gene Symbol
Dmd
Model Description
Validation Data
Fig1 Mouse dystrophin expression is abolished due to the p.Q995X mutation.
Fig2 Histopathology of WT and MDX mice(male, 6-month-old) muscle showing less uniform muscle fibers with inflammation and clustered nuclei.
Fig3 Limb grip strength tests in MDX mice.
The assessment of limb strength in experimental mice were performed by means of grip strength meter (BIO-G53, Bioseb, France). The mice were allowed to grab the pull bar and are then gently pulled backwards. The force applied to the bar just before it loses grip was recorded as peak resistance force (expressed in grams). To reduced procedure-related variability, the tests were repeated 4 to 5 times and the average was recorded.
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