hFCRN/hALB(SD)

Fig.1 Detection of ALB expression in serum by blood biochemical analysis (n=4). 

Abbr. HO, homozygous; WT, wild type.

Fig.2 Detection of hALB (A) and rALB (B) expression in serum by ELISA (n=3). 

Abbr. HO, homozygous; WT, wild type.

Fig.3 Detection of human ALB expression in serum of WT SD and hALB/hFCRN (SD) rat by ELISA. Human ALB was exclusively detectable in hALB(SD) rat. Serum were collected from wild-type SD (n=3) and HO hALB/hFCRN (SD) rat (n=3, 9 weeks old), and analyzed by ELISA. 

Abbr. WT, wild type; HO, homozygous.

Fig.4 Expression characterization of hFCRN in hALB/hFCRN dKI rat by Western blot. (Arrow indicates expected molecular weight and asterisk indicates a nonspecific band)   

Fig.5 Blood concentration curve of test articles in hFcRn/hALB dKI rats. 

In hFcRn/hALB dKI rats, the half-life time: TA-N434A > TA-YTE > TA. (In cooperation with the third party) 

Fig.6 PK study of Keytruda in  hALB/hFCRN dKl rat. (n=3/time point/group)  

Fig.7 PK study of Cyramza in hALB/hFCRN dKI rat. (n=3/time point/group)