Ifng-Venus-Luc
Nomenclature
C57BL/6Smoc-Ifngem1(IRES-Venus-Luci)Smoc
Cat. NO.
NM-KI-18041
Strain State
Repository Live
Gene Summary
Gene Symbol
Ifng
Model Description
Validation Data
Fig1.MC38-OVA tumor volumes in Ifng-Venus-Luci reporter mice treated or not with anti-PD-1 mAb. Arrows indicate treatment days.
Fig2. In vivo imaging validation of MC38-OVA tumors in Ifng-Venus-Luci reporter mice treated or not with anti-PD-1 mAb.
In PBS treated control tumor, the IFNγ signal increased as the tumor growing. In anti-PD1 treated tumor, increased average BLI (Bioluminescent imaging) of IFNγ was shown 48h post the first dose compared to control group; as the tumor regression upon PD1 treatment, the IFNγ signal in tumor decreased as well.
The data is provided by Crownbio.
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