Thy1-CreERT2
Nomenclature
C57BL/6Smoc-Thy1em1(Kozak-CreERT2-WPRE-pA)Smoc
Cat. NO.
NM-KI-231054
Strain State
Sperm cryopreservation
Gene Summary
Gene Symbol
Thy1
Model Description
Validation Data
Fig1. Detection of tdTomato expression on CD90+ cells in BM, spleen and blood.
In tamoxifen-treated HE/HE Thy1-CreERT2/R26-CAG-LSL-tdTomato mice, most CD90+ cells were tdTomato+ in bone marrow (~70 %), spleen (~90 %) and blood (~95 %).
Fig2. Detection of CD90 expression on tdTomato+ cells in BM, spleen and blood.
In HE/HE Thy1-CreERT2/R26-CAG-LSL-tdTomato mice, most tdTomato+ cells were CD90+ in bone marrow (~60 %), spleen (~90 %) and blood (66.5~89.4 %).
b
Fig3. CreERT2 mediated recombination in brain(Purkinje cell) of Thy1CreERT2/+;Rosa26 tdTomato/+ mice
Fig4. Detection of tdTomato(red) in various tissues of Thy1CreERT2/+;Rosa26 tdTomato/+ mouse.
Organs and tissues with tdTomato expression following tamoxifen induction include: brain, spinal cord, large intestine, small intestine, stomach, liver, heart, lungs, salivary glands, spleen, skin, pancreas, reproductive system, adrenal glands, kidneys, thymus, and eyeballs.
Tissues with expression leakage in the uninduced group include: brain, salivary glands, skin, reproductive system, and eyes (retina).(119-days old, female and male) (For more detailed information please contact our technical advisor.)
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