Nmu-2A-Cre

Nomenclature

C57BL/6Smoc-Nmuem1(2A-Cre-WPRE-polyA)Smoc

Cat. NO.

NM-KI-200298

Strain State

Repository Live

Export PDF

Gene Summary

Gene Symbol
Nmu

Synonyms

-

NCBI ID

56183

MGI ID

1860476

Ensembl ID

ENSMUSG00000029236

Pubmed

Nmu

Human Ortholog

NMU

Model Description

2A-Cre-WPRE-polyA expression cassette was knocked into the Nmu gene stop codon site. Nmu gene encodes a member of the neuromedin family of neuropeptides. The encoded protein plays a role in energy homeostasis and body temperature regulation. And the protein is homologous with human NMU, which is linked toobesity.
Research Application：Cre recombinase tool; Neuroscience

Validation Data

image.png

Fig. 1 Cre-mediated recombination in the intestine of NmuCre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the submucosal plexus (red arrows) of NmuCre/+; Rosa26tdTomato/+ mouse.

image.png

Fig. 2 Cre-mediated recombination in the intestine of NmuCre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the substantia nigra pars reticulate(SNR) of NmuCre/+; Rosa26tdTomato/+ mouse.

image.png

Fig. 3 Detection of tdTomato(red) in various tissues of NmuCre/+; Rosa26tdTomato/+ mice. Cre-mediated recombination can be detected in some cells of the heart, intestine, colon, pancreas, ovary, uterus, thymus, stomach. Tdtomato can also be detected in individual cells of the brown fat, kidney, lung, liver, muscle, salivary gland, skin and spleen. (For more detailed information please contact our technical advisor.)


You may also like

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

Learn more
Workshop：Progress and Advances in Preclinical immuno-Oncology Research

SMOC’s Annual Progress and Advances in Preclinical immuno-Oncology Research: The workshop is designed as a forum for ideas and opinions exchange on how to decrease the rate of clinical failures in oncology and immuno-oncology.

Learn more