Myl2-Cre-IRES-EGFP

Nomenclature

C57BL/6Smoc-Myl2em1(Cre-IRES-EGFP-WPRE-polyA)Smoc

Cat. NO.

NM-KI-200224

Strain State

Sperm cryopreservation

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Gene Summary

Gene Symbol
Myl2

Synonyms

MLC-2; Mlc2v; Mylpc; MLC-2v; MLC-2s/v

NCBI ID

17906

MGI ID

97272

Ensembl ID

ENSMUSG00000013936

Pubmed

Myl2

Human Ortholog

MYL2

Model Description

A Cre-IRES-EGFP-WPRE-polyA expression cassette was knocked into the Myl2 gene start codon site.
Research Application：These mice express cre recombinase from the Myl2 locus. This strain may be useful for studying cardiogenesis.

Validation Data

NM-KI-200224 Myl2-Cre-IRES-EGFP-1.png

Fig.1 Cre-mediated recombination in the heart of Myl2Cre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the ventricular cardiomyocytes and few atrial cells of Myl2Cre/+; Rosa26tdTomato/+ mouse. EGFP(green) expression can not be observed.

NM-KI-200224 Myl2-Cre-IRES-EGFP-2.png

Fig. 2 Detection of tdTomato(red) and GFP(green) in various tissues of Myl2Cre/+; Rosa26tdTomato/+ mice. Cre mediated recombination can be detected in the heart, few cells of thymus, bronchus, submandibular gland, skin, kidney and choroid plexus of fourth ventricle. Tdtomato expression can not be observed in the brown fat, liver, stomach, intestine, colon, spleen, pancreas, testis and epididymis. EGFP expression can not be observed.(For more detailed information please contact our technical advisor.)

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