Pbsn-2A-CreERT2

Nomenclature

C57BL/6JSmo-Pbsnem1(V5-2A-CreERT2-WPRE-polyA)Smoc

Cat. NO.

NM-KI-200190

Strain State

Repository Live

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Gene Summary

Gene Symbol
Pbsn

Synonyms

PB; Prbs

NCBI ID

54192

MGI ID

1860484

Ensembl ID

ENSMUSG00000000003

Pubmed

Pbsn

Human Ortholog

PBSN

Model Description

A V5-2A-CreERT2-WPRE-polyA expression cassette was knocked into the Pbsn gene stop codon site.
Research Application：Cre recombinase tool,epithelial cells of the prostate.

Validation Data

pbsn.png

Fig1. Expression Pattern of Tomato in PbsnCreERT2/+;Rosa26tdTomato/+ mice.

CreERT2-mediated recombination in prostate epithelial cells of PbsnCreERT2/+ ; Rosa26tdTomato/+ mice. This strain represents an effective tool for generating prostate specific-targeted mutants.

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Fig2. Cre mediated recombination in prostate of PbsnCreERT2/+;Rosa26tdTomato/+ mouse. 

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Fig3. Detection of tdTomato(red) in various tissues of PbsnCreERT2/+;Rosa26tdTomato/+ mouse. Expression tissues include: prostate, salivary gland. A few cells expressed in adrenal gland, pancreas, testis, muscle and thymus. Tissues that unexpressed include brain, spinal cord, eyeball, heart, lung, liver, stomach, brown fat, kidney, colon, small intestine, spleen, and skin. (9-week old, male) (For more detailed information please contact our technical advisor.)

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