Lgr5-2A-DreERT2

Nomenclature

C57BL/6Smoc-Lgr5em1(2A-DreERT2)Smoc

Cat. NO.

NM-KI-200178

Strain State

Sperm cryopreservation

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Gene Summary

Gene Symbol
Lgr5

Model Description

A 2A-DreERT2 expression cassette was knocked into the Lgr5 gene stop codon site.
Research Application:Dre recombinase tool

Validation Data

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Fig1. Dre mediated recombination in liver of Lgr5DreERT2/+; Rosa26tdTomato/+ mouse.

Hepatocyte expressing tdTomato(red) after tamoxifen induction of Lgr5DreERT2/+; Rosa26tdTomato/+ mouse. (see the reference). 

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Fig2. Dre mediated recombination in colon of Lgr5DreERT2/+; Rosa26tdTomato/+ mouse.

Lgr5-2A-DreERT2 43T,46.jpg

Fig3. Detection of tdTomato(red) in various tissues of Lgr5DreERT2/+; Rosa26tdTomato/+ mouse. 

Tissues expressing tdTomato after tamoxifen induction included the large intestine, small intestine, liver, stomach, and skin. In contrast, no significant fluorescent expression was observed in the brain, spinal cord, esophagus, muscle, vagina, or reproductive system of the mice following tamoxifen induction. (38-days old, female) (For more detailed information please contact our technical advisor.) 



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