Ntrk2-CreERT2

Nomenclature

C57BL/6JSmo-Ntrk2em1(CreERT2-WPRE-polyA)Smoc

Cat. NO.

NM-KI-200146

Strain State

Sperm cryopreservation

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Gene Summary

Gene Symbol
Ntrk2

Synonyms

Tkrb; trkB; trk-B; GP145-TrkB/GP95-TrkB

NCBI ID

18212

MGI ID

97384

Ensembl ID

ENSMUSG00000055254

Pubmed

Ntrk2

Human Ortholog

NTRK2

Model Description

A CreERT2-WPRE-polyA expression cassette was knocked into the Ntrk2 gene start codon site. Ntrk2 encodes the tropomyosin receptor kinase B (TrkB), transmission through which neurotrophic factors modify differentiation, plasticity, and synaptic transmission. When these Ntrk2-CreERT2 mice are bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the flanked sequences in Ntrk2 expressing cells.
Research Application：Cre recombinase tool; Neuroscience

Validation Data

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Fig. 1 CreERT2-mediated recombination in the multiple brain regions of Ntrk2-CreERT2; Rosa26-tdTomato mice after tamoxifen treatment.

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Fig. 2 CreERT2-mediated recombination in individual cells in the lungs of Ntrk2-CreERT2; Rosa26-tdTomato mice after tamoxifen treatment.

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Fig. 3 Tdtomato was also abundantly expressed in brown fat, and expressed in thymus, salivary gland, spleen, large intestine, stomach and skin. There was a small amount of expression in kidney, and no expression in the heart, small intestine and muscle.（For more information please contact: 400-728-0660.）



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