Il17a-Cre

Nomenclature

C57BL/6Smoc-Il17aem1(iCre-polyA(SV40))Smoc

Cat. NO.

NM-KI-200137

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
IL17A

Synonyms

Il17; Ctla8; IL-17; Ctla-8; IL-17A

NCBI ID

16171

MGI ID

107364

Ensembl ID

ENSMUSG00000025929

Pubmed

IL17A

Human Ortholog

IL17A

Model Description

A iCre-polyA expression cassette was knocked into the Il17a gene start codon site. This gene encodes a pro-inflammatory cytokine that is a member of the interleukin-17 family. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre. This strain may be useful for studying autoimmune inflammatory diseases such as rheumatoid arthritis, psoriasis and multiple sclerosis.
Research Application：Cre recombinase tool; T helper cell

Validation Data

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Fig 1. Cre mediated recombination in lung of Il17aCre/+;Rosa26tdTomato/+ mouse. 

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Fig 2. Cre mediated recombination in mesenteric lymph nodes of Il17aCre/+;Rosa26tdTomato/+ mouse. 

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