Slc6a4-Cre

A iCre-pA expression cassette was knocked into the Slc6a4 gene start codon site. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing Cre. The gene product has been involved in the neurological disorders such as addiction and depression.

Fig. 1 Cre-mediated recombination in the brain of Slc6a4^Cre/+; Rosa26^tdTomato/+ mouse. TdTomato(red) expression can be detected in the cortex, thalamus and olfactory bulb of Slc6a4^Cre/+; Rosa26^tdTomato/+ mouse.

Fig. 2 Detection of tdTomato(red) in various tissues of Slc6a4^Cre/+; Rosa26^tdTomato/+ mice. Tdtomato expression can be detected in the cortex, thalamus, heart, bronchi, liver, stomach, salivary gland, skin, testis, kidney, thymus, spleen, pancreas, intestine and colon. Tdtomato expression can not be detected in the retina or muscle. (For more detailed information please contact our technical advisor.)