Foxn1-IRES-Cre

A IRES-iCre expression cassette was knocked into the Foxn1 gene stop codon site. The protein encoded by Foxn1 (forkhead box N1) gene is part of the forkhead family or transcription factors that are important in developmental processes, immune system regulation, metabolism, cancer and aging. When crossed with a strain carrying a gene flanked by sites, the flanked gene will be removed in thymic epithelial cell and keratinocytes.

Fig. 1 Cre-mediated recombination in the thymus of Foxn1^Cre/+; Rosa26^tdTomato/+ mouse. TdTomato(red) expression can be detected in the thymus of Foxn1^Cre/+; Rosa26^tdTomato/+ mouse.

Fig. 2 Detection of tdTomato(red) in various tissues of Foxn1^Cre/+; Rosa26^tdTomato/+ mice. Cre-mediated recombination can be detected in some cells of the thymus, skin, stomach, uterus and in individual cells of the colon, eye, kidney, lung, pancreas. Tdtomato can not be detected in the brain, muscle, heart, liver, ovary, intestine or spleen. (For more detailed information please contact our technical advisor.)