Etv1-CreERT2

A CreERT2 expression cassette was knocked into the Etv1 gene start codon site. ETV1 expression is enriched in fast conduction tissues of embryonic and adult mammalian hearts. And ETV1 expression is upregulated in the atrial tissue of patients with permanent atrial fibrillation. Etv-CreERT2 mice can be applied to heart disease research. ETV1 is also expressed in retinal ganglion cells of adult mice, and the mouse model can be used to study how retinal ganglion cells contribute to visual processing in the brain.

Fig. 1 Detection of tdTomato (red) in the heart of Etv1CreERT2/+; Rosa26tdTomato/+  mouse. CreERT2-mediated recombination in some of the left atrium and right ventricle cells of Etv1CreERT2/+; Rosa26tdTomato/+ mouse after tamoxifen treatment. 

Fig. 2 Detection of tdTomato (red) in the retina of Etv1CreERT2/+; Rosa26tdTomato/+  mouse after tamoxifen treatment. CreERT2-mediated recombination in the retinal ganglion cell layer (green arrowhead) and inner nuclear layer (yellow arrowhead) of Etv1CreERT2/+; Rosa26tdTomato/+ mouse can be induced by tamoxifen. 

Fig. 3 Detection of tdTomato (red) in various tissues of Etv1CreERT2/+; Rosa26tdTomato/+ mice. 

CreERT2-mediated recombination in the heart and retina can be induced by tamoxifen. And tdTomato expression can also be observed in the brain, lung, stomach, colon, intestine, kidney and pancreas, but not in liver.