Oxt-IRES-Cre

Nomenclature

C57BL/6Smoc-Oxtem1(IRES-iCre)Smoc

Cat. NO.

NM-KI-200090

Strain State

Sperm cryopreservation

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Gene Summary

Gene Symbol
Oxt

Synonyms

OT; Oxy

NCBI ID

18429

MGI ID

97453

Ensembl ID

ENSMUSG00000027301

Pubmed

Oxt

Human Ortholog

OXT

Model Description

A IRES-iCre expression cassette was knocked into the Oxt gene stop codon site.
Research Application：Cre recombinase tool; Oxt-IRES-Cre mice express Cre recombinase under the control of the endogenous oxytocin (Oxt) promoter. Cre recombinase is expressed in the brain. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in neurons expressing oxytocin.

Validation Data

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Fig. 1 Cre-mediated recombination in the brain of OxtCre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the olfactory bulb, cortex, thalamus and cerebellum derived from OxtCre/+; Rosa26tdTomato/+ mouse.

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Fig. 2 Cre-mediated recombination in the eyes of OxtCre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the retinal inner nuclear layer and ganglion cell layer derived from OxtCre/+; Rosa26tdTomato/+ mouse. 

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Fig. 3 Detection of tdTomato(red) in various tissues of OxtCre/+; Rosa26tdTomato/+ mice. Cre mediated recombination can be detected in some cells of the brain, retina, pituitary gland, heart, lung, liver, salivary gland, brown fat, kidney, pancreas, intestine, colon, spleen, ovary, skeletal muscle, skin and thymus. (For more detailed information please contact our technical advisor.)


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