Foxp3-IRES-tdTomato-2A-CreERT2

Nomenclature

C57BL/6Smoc-Foxp3em4(IRES-tdTomato-2A-CreERT2)Smoc

Cat. NO.

NM-KI-190120

Strain State

Repository Live

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Gene Summary

Gene Symbol
Foxp3

Synonyms

sf; JM2; scurfin

NCBI ID

20371

MGI ID

1891436

Ensembl ID

ENSMUSG00000039521

Pubmed

Foxp3

Human Ortholog

FOXP3

Model Description

A IRES-tdTomato-2A-CreERT2 expression cassette was knocked into the Foxp3 gene stop codon site.
Research Application：Cre tool mouse

Validation Data

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Fig1. Detection of tdTomato and zsGreen expressed on mCD4+ mFoxp3+ Treg cells  in Peripheral blood and spleen in WT and Foxp3CreERT2/+; Rosa26zsGreen/+ mice.

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Fig2. CreERT2 mediated recombination in large intestine of Foxp3 CreERT2/+;Rosa26 zsGreen/+ mice.

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Fig3. Detection of zsGreen(green) and tdTomato(red) in various tissues of Foxp3 CreERT2/+;Rosa26 zsGreen/+ mice. Tissues expressing zsGeen: large intestine, small intestine, lung, stomach, spleen, pancreas, skin, thymus, mesenteric lymph nodes. Tissues expressing zsGeen in small amounts: liver, kidney. (58-days old, male) (For more detailed information please contact our technical advisor.) 

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