MHC ClassII(I-A/I-E)-KO(NMG)
Nomenclature
NOD-PrkdcscidIl2rgem1H2-Ab1em1H2-Aaem1H2-Eb1em1H2-Eb2em1H2-Ea-ps em1Smoc
Cat. NO.
NM-NSG-003
Strain State
Developing
Gene Summary
Gene Symbol
H2-Ab1
Gene Symbol
H2-Aa
Gene Symbol
H2-Eb1
Gene Symbol
H2-Eb2
Model Description
All sequences from the upstream of mouse H2-Ab1 gene exon 2 to the upstream of the H2-Ea-ps gene exon 1 were knocked out to obtain H2-Ab1、H2-Aa、H2-Eb1、H2-Eb2、H2-Ea-ps knockout mouse models. These MHC class II molecule-deficient mice were on the NMG genetic background and also lacked cell surface expression of both class II-A and class II-E MHC proteins.
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