MHC Class II (I-A/I-E) -KO

Nomenclature

C57BL/6Smoc-H2-Ab1em1H2-Aaem1 H2-Eb1em1H2-Eb2em1H2-Ea-ps em1 Smoc

Cat. NO.

NM-KO-18032

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol

Synonyms

Abeta A beta H-2Ab H2-Ab Ia2 Ia-2 IAb I-Ab I-Abeta Rmcs1，Aalpha A alpha H-2Aa Ia1 Ia-1 I-Aalpha，H-2Eb Ia4 Ia-4，A130038H09Rik H-2Eb2 Ia5 Ia-5，H-2Ea Ia3 Ia-3 I-Ealpha

NCBI ID

14961，14960，14969，381091，100504404

MGI ID

103070，95895，95901，95902，95900

Ensembl ID

ENSMUSG00000073421，ENSMUSG00000036594，ENSMUSG00000060586 ，ENSMUSG00000067341，ENSMUSG00000036322

Pubmed

Human Ortholog

HLA-DQB1，HLA-DQA1，HLA-DRB5，HLA-DRA

Model Description

All sequences from the upstream of mouse H2-Ab1 gene exon 2 to the upstream of the H2-Ea-ps gene exon 1 were knocked out to obtain H2-Ab1、H2-Aa、H2-Eb1、H2-Eb2、H2-Ea-ps knockout mouse models. These MHC class II molecule-deficient mice were on the C57BL/6J genetic background and also lacked cell surface expression of both class II-A and class II-E MHC proteins.
Research Application：immune system

Validation Data

image.png

Fig.1 Detection of MHC Class II (I-A/I-E) expression in blood of female HO MHC Class II (I-A/I-E) -KO mice. 

Abbr.  WT, wild type; HO, homozygous.

image.png

Fig.2 Detection of MHC Class II (I-A/I-E) expression in spleen of female HO MHC Class II (I-A/I-E) -KO mice. 

Abbr.  WT, wild type; HO, homozygous.

image.png

Fig.3 Detection of immune cell subsets in blood and spleen of HO MHC Class II (I-A/I-E) -KO mice (two female mice in both groups).

Abbr.  WT, wild type; HO, homozygous.

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