Cdkn2a-Luc-2A-tdTomato-2A-CreERT2(p16-Luc-2A-tdTomato-2A-CreERT2)

Nomenclature

C57BL/6Smoc-Cdkn2aem(Luc-tdTomato-CreERT2)Smoc

Cat. NO.

NM-KI-18039

Strain State

Repository Live

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Gene Summary

Gene Symbol
Cdkn2a

Synonyms

Arf; p16; MTS1; Pctr1; p19ARF; p16INK4a; p19; ARF-INK4a; INK4a-ARF; Ink4a/Arf; p16(INK4a)

NCBI ID

12578

MGI ID

104738

Ensembl ID

ENSMUSG00000044303

Pubmed

Cdkn2a

Human Ortholog

CDKN2A

Model Description

A Luc-2A-tdTomato-2A-CreERT2-WPRE-pA cassette was fused in-frame with exon2 of p16INK4a transcript such that the exogenous proteins would be translated followed by the first 62aa of Cdkn2a.

Validation Data


Cdkn2a-2.png

Fig1  Luciferase reporter assays in MEF cells(WT and Cdkn2a KI MEFs).

Publications

Senescent-like macrophages mediateangiogenesis for endplate sclerosis via IL-10secretioninmalemice
References：Nature Communications

Reference(s)

Senescent-like macrophages mediateangiogenesis for endplate sclerosis via IL-10secretioninmalemice
References：Nature Communications

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