M-SDR
Nomenclature
SD-Rag2em1Smoc
Cat. NO.
NR-KO-190001
Strain State
Repository Live
Gene Summary
Gene Symbol
Rag2
Model Description
Exon 3 of Rag2 gene was deleted to generate Rag2 knockout rat.
Research Application：immune system
*Literature published using this strain should indicate: M-SDR rats (Cat. NO. NR-KO-190001) were purchased from Shanghai Model Organisms Center, Inc..
Validation Data
Fig1. Rag2-KO rat immunotypes analysis.
Fig2. The establishment of tumor models in Rag2-KO rats using HCT116 cells.
Fig3. Blood Routine Tests in Rag2-KO(SD) rats.
Fig4. Blood biochemistry in Rag2-KO(SD) rats.
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Cre-ERT2在无Tamoxifen诱导的情况下，在细胞质内处于无活性状态；当Tamoxifen诱导后，Tamoxifen的代谢产物4-OHT（雌激素类似物）与ERT结合，可使Cre-ERT2进核发挥Cre重组酶活性。
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