B2m-KO(NMG)

Nomenclature

M-NSG-B2memSmoc

Cat. NO.

NM-NSG-002

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
B2M

Synonyms

y-m11; beta2m; beta2-m

NCBI ID

12010

MGI ID

88127

Ensembl ID

ENSMUSG00000060802

Pubmed

B2M

Human Ortholog

B2M

Model Description

This B2m knockout mouse model was obtained by knocking out the exon 2-3 region of mouse B2m gene on the background of NMG mouse.
Research Application：immunodeficiency,immune system,transplantation research

Validation Data

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Fig 1. Expression characterization of mouse MHC I and MHC II in bone marrow, blood, spleen in B2m-KO(NMG) mice.

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Fig 2. Body weight growth curve of huPBMC-B2m-KO(NMG) mice.

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Fig 3. Survival rate of huPBMC-B2m-KO(NMG) mice.

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Fig 4. GvHD scores of huPBMC-B2m-KO(NMG) mice.

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Fig 5. Percentage of hCD45-positive cells of huPBMC-B2m-KO(NMG) mice.

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Fig 6. Flow analysis of peripheral blood lymphocyte subpopulations in the huPBMC-B2m-KO(NMG) mice.

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