hVISTA

Nomenclature

C57BL/6JSmo-Vsirtm1(hVSIR)/Smoc

Cat. NO.

NM-HU-00118

Strain State

Repository Live

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Gene Summary

Gene Symbol
Vsir

Synonyms

Dies1; PD-1H; VISTA; 4632428N05Rik

NCBI ID

74048

MGI ID

1921298

Ensembl ID

ENSMUSG00000020101

Pubmed

Vsir

Human Ortholog

VSIR

Model Description

The exon 2-3 of endogenous mouse Vsir gene was replaced by the exon 2-3 of human VSIR(VISTA) gene.
Research Application：Immunotherapy,cancer research,drug screening

Validation Data

vista表达验证数据_03-1.png

Figure 1. Detection of VISTA expression in peripheral blood cells of humanized VISTA mice.

The expression of human VISTA was detected by FACS. The results showed that the active expression of human VISTA can be detected in both activated CD4+ and CD8+ T lymphocytes collected from humanized VISTA mice.

图片1.png

Figure 2. In vivo validation of anti-tumor efficacy in a MC38 tumor-bearing model of humanized VISTA mice. 

Humanized VISTA mice were inoculated with MC38 colon cancer cells,the animals were randomly assigned into a control group and a treatment group (n=6). The drug was administered on days 0, 3, 7, 10, 14, and 17 respectively.The antibody showed significant tumor inhibition at the recommended dose(TGI: tumor growth inhibition, p < 0.01). (Cooperation with WuXi Biologics)

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