hCD3EDG

Nomenclature

C57BL/6-Cd3etm1(hCD3E)Cd3dtm1(hCD3D)Cd3gtm1(hCD3G)/CbSmoc

Cat. NO.

NM-HU-220120

Strain State

Repository Live

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Gene Summary

Gene Symbol
CD3E

Gene Symbol
CD3D

Gene Symbol
CD3G

Model Description

The endogenous mouse Cd3e/Cd3d/Cd3g genes were replaced by human CD3E/CD3D/CD3G gene.

Validation Data

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Fig 1. Homozygous hCD3EDG mice were engrafted with MC38-hCLDN18.2 to eveluate the in vivo efficacy of anti-CD3×Claudin18.2 bispecific antibody in parallel with homozygous hCD3EDG mice.

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Fig 2. Homozygous hCD3EDG mice were engrafted with MC38-hEpCAM to eveluate the AICD and irAE of OKT3 and anti-CD3×EpCAM bispecific antibody in vivo.


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