hCD3EDG/hCD19

Nomenclature

C57BL/6Smoc-Cd3etm1(hCD3E)Cd3dtm1(hCD3D)Cd3gtm1(hCD3G)Cd19em1(hCD19) /Smoc

Cat. NO.

NM-HU-220109

Strain State

Repository Live

Export PDF

Model Description

hCD3EDG(NM-HU-220120) mice were crossed with hCD19(NM-HU-00110) mice to generate hCD3EDG/hCD19 mice.

Validation Data

image.png

Fig.1 Detection of immune phenotype in WT C57BL/6 and HO/HO hCD3EDG/hCD19 mice.

image.png

Fig.2 Detection of phenotype in Peripheral blood in WT C57BL/6 and HO/HO hCD3EDG/hCD19 mice.

image.png

Fig.3 Detection of phenotype in Spleen in WT C57BL/6 and HO/HO hCD3EDG/hCD19 mice.

image.png

Fig.4 Detection of phenotype in Lymph node in WT C57BL/6 and HO/HO hCD3EDG/hCD19 mice.

image.png

Fig.5 Detection of CD3 and CD19 expression in Blood in hCD3EDG/hCD19 dKI and WT mice

image.png

Fig.6 The Body weight of HO/HO hCD3EDG/hCD19 mice. 

image.png

Fig.7 Detection of mIgG (A) and mIgM (B) expression in serum in WT C57BL/6 and HO/HO hCD3EDG/hCD19 mice by ELISA. (n=6)

Abbr. WT, wild type.

image.png

Fig.8 Detection of immune phenotype in peripheral blood in HO/HO hCD3EDG/hCD19 mice.

image.png

Fig.9 The weight of different tissues in HO/HO hCD3EDG/hCD19 mice.

Table.1 Blood routine examination in hCD3EDG/hCD19 dKI mice (n=6 /group).

WechatIMG692.jpg

WechatIMG693.jpg

You may also like

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

Learn more
Workshop：Progress and Advances in Preclinical immuno-Oncology Research

SMOC’s Annual Progress and Advances in Preclinical immuno-Oncology Research: The workshop is designed as a forum for ideas and opinions exchange on how to decrease the rate of clinical failures in oncology and immuno-oncology.

Learn more