hHER3(2)

Nomenclature

C57BL/6Smoc-Erbb3tm2(hERBB3)Smoc

Cat. NO.

NM-HU-225068

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
Erbb3

Synonyms

Her3; C76256; Erbb-3; Erbb3r

NCBI ID

13867

MGI ID

95411

Ensembl ID

ENSMUSG00000018166

Pubmed

Erbb3

Human Ortholog

ERBB3

Model Description

The endogenous mouse Erbb3 gene was replaced by human ERBB3 gene.

Validation Data

image.png

Fig.1 Detection of ERBB3 expression in colon by RT-PCR. 

Wild type: only one band at 343 bp with primers F1/R1(mErbb3);

Homozygous: only one band at 305 bp with primers F2/R2(hERBB3).

Abbr. M, DNA marker; HO, homozygous; WT, wild type.

image.png

Fig.2 Detection of human hHER3 expression in hHER3(2) knockin mice by WB. 

Abbr. M, marker; WT, wild type; HO, homozygous; PC, positive control, MC38-hHER3 cells.

Note. The anti-human hHER3 antibody cross-reacted with mouse hHER3 and humanized hHER3. 

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