hTP53(2)

Nomenclature

C57BL/6Smoc-Trp53tm2(hTP53)Smoc

Cat. NO.

NM-HU-225052

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
Trp53

Synonyms

bbl; bfy; bhy; p44; p53; Tp53

NCBI ID

22059

MGI ID

98834

Ensembl ID

ENSMUSG00000059552

Pubmed

Trp53

Human Ortholog

TRP53

Model Description

The endogenous mouse Trp53 gene was replaced by human TP53 gene.

Validation Data

image.png

Fig.1 Detection of TP53 expression in thymus by RT-PCR. 

Wild type: only one band at 229 bp with primers F1/R1(mTrp53);

Homozygous: only one band at 344 bp with primers F2/R2(hTP53).

Abbr. M, DNA marker; HO, homozygous; WT, wild type.

image.png

Fig.2 Detection of human P53 expression in hTP53(2) knockin mice by WB. 

Abbr. M, marker; WT, wild type; HO, Homozygous.

Note. The anti-human P53 antibody cross-reacted with mouse P53 and humanized P53. hTP53(2) and C57BL/6 mice were i.p. injected with LPS.

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