hCLDN6

Nomenclature

C57BL/6Smoc-Cldn6tm1(hCLDN6)Smoc

Cat. NO.

NM-HU-225034

Strain State

Embryo cryopreservation

Export PDF

Gene Summary

Gene Symbol
Cldn6

Synonyms

AL024037

NCBI ID

54419

MGI ID

1859284

Ensembl ID

ENSMUSG00000023906

Pubmed

Cldn6

Human Ortholog

CLDN6

Model Description

The endogenous mouse Cldn6 gene was replaced by human CLDN6 gene.

Validation Data

image.png

Fig.1 Detection of CLDN6 expression in lung by RT-PCR. 

Wild type: only one band at 304 bp with primers F1/R1(mCldn6);

Homozygous: only one band at 141 bp with primers F2/R2(hCLDN6).

Abbr. M, DNA marker; HO, homozygous; WT, wild type.

image.png

Fig.2 Detection of human CLDN6 expression in hCLDN6 knockin Mice by WB. 

Abbr. M, marker; WT, wild type; HO, Homozygous.

Note. The anti-human CLDN6 Antibody cross-reacted with mouse CLDN6 and humanized CLDN6. 

You may also like

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

Learn more
Workshop：Progress and Advances in Preclinical immuno-Oncology Research

SMOC’s Annual Progress and Advances in Preclinical immuno-Oncology Research: The workshop is designed as a forum for ideas and opinions exchange on how to decrease the rate of clinical failures in oncology and immuno-oncology.

Learn more