hIL1A

Nomenclature

C57BL/6Smoc-Il1atm1(hIL1A)Smoc

Cat. NO.

NM-HU-215071

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
Il1a

Synonyms

Il-1a

Chromosome

2

NCBI ID

16175

MGI ID

96542

Ensembl ID

ENSMUSG00000027399

Pubmed

Il1a

Human Ortholog

IL1A

Model Description

The endogenous mouse Il1a gene was replaced by human IL1A gene.

Validation Data

image.png

Fig.1 Detection of IL1A expression in spleen and lung by RT-PCR. 

Wild type: only one band at 324 bp with primers F1/R1(mIl1a);

Homozygous: only one band at 265 bp with primers F2/R2(hIL1A).

Abbr. M, DNA marker; HO, homozygous; WT, wild type.

image.png

Fig.2 Detection of hIL1A expression in bone marrow by ELISA (n=3). 

Abbr.  WT, wild type; HO, homozygous; N.D. not detected.

Note.  Monocytes derived from bone marow were stimulated with LPS in vitro for 24h.

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