hIL21R

Nomenclature

C57BL/6Smoc-Il21rtm1(hIL21R)Smoc

Cat. NO.

NM-HU-210031

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
IL21R

Model Description

The endogenous mice Il21r gene was completely or partially replaced by human IL21R gene via ESC targeting.
Research Application:inmmue therapy;drug screening

Validation Data

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Fig.1 Detection of IL21R expression in spleen and thymus by RT-PCR in hPD-1/hIL21R dKI mice which were generated by crossing hIL21R(NM-HU-210031) with hPD-1(NM-HU-00015).

Wild type: only one band at 189 bp with primers F1/R1(mIl21r);

Homozygous: only one band at 177 bp with primers F2/R2(hIL21R).

Abbr. M, DNA marker; HO, homozygous; WT, wild type.

image.png

Fig.2 Detection of hIL21R expression in activated splenocyte in WT C57BL/6 and HO hPD-1/hIL21R dKI mice which were generated by crossing hIL21R(NM-HU-210031) with hPD-1(NM-HU-00015).



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