hHLA-DPA1*03: 01

Nomenclature

C57BL/6Smoc-H2-Aatm1(hHLA-DPA1*03: 01)Smoc

Cat. NO.

NM-HU-210009

Strain State

Repository Live

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Gene Summary

Gene Symbol
H2-Aa

Synonyms

Ia1; H2Aa; Ia-1; H-2Aa; Aalpha; IAalpha; I-Aalpha

NCBI ID

14960

MGI ID

95895

Ensembl ID

ENSMUSG00000036594

Pubmed

H2-Aa

Human Ortholog

HLA-DQA1

Model Description

The endogenous mice H2-Aa gene was replaced by human HLA-DPA1*03: 01 gene
Research Application：inmmue therapy；drug screening

Validation Data

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Fig.1 Detection of HLA-DPA1 expression in large Intestine by RT-PCR. Wild type:  one band at 429 bp with primers F1/R1 (mHla-dpa1); Homozygous: one band at 256 bp with primers F2/R2 (hHLA-DPA1). Abbr. M, DNA marker; HO, homozygous; WT, wild type.

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Fig2. Expression characterization of hHLA-DP on human PBMC.

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Fig3. Expression characterization of HLA-DPA1*03:01 on DCs in Blood in HLA-DPA1*03:01 KI mice. Note: The anti-hMHC II antibody has been reported to react with a shared epitope of HLA-DR, HLA-DP, and HLA-DQ. The anti-mMHC II antibody reacts with a polymorphic determinant shared by the I-Ab, I-Ad, I-Aq, I-Ed, and I-Ek MHC class II alloantigens from mice carrying H-2p,r,q,b,d,u haplotypes.

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