hOX40/hOX40L(2)

Nomenclature

C57BL/6Smoc-Tnfrsf4tm1(hTNFRSF4)Tnfsf4tm2(hTNFSF4)/Smoc

Cat. NO.

NM-HU-200263

Strain State

Embryo cryopreservation

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Model Description

hOX40L(2)(NM-HU-200005)was crossed with hOX40(NM-HU-00041)to generate hOX40/hOX40L(2)mice

Validation Data

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Fig1. OX40 expression on CD4+ T cells in spleen in hOX40 KI mice.

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Fig2. OX40 expression on Treg cells in spleen in hOX40 KI mice. 

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Fig3. Detection of hOX40L expression on stimulated APCs in hOX40/hOX40L dKI mice.

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Fig4. OX40 antibody showed dose-dependent anti-tumor activity in human OX40 knock-in mice bearing MC38 tumors.(The OX40 antibody was obtained from Innoventbio)

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