hHER2

Fig1. Detection of HER2 expression by RT-PCR. 

Wild type: only one band at 375 bp with primers F1/R1 (mHer2);

Homozygous: one band at 223 bp with primers F2/R2 (hHER2).

Abbr. M, DNA marker; HO, homozygous;  WT, wild type.

Fig2. Detection of HER2 expression in homozygous hHER2 mice by Western Blot. 

Note: The HER2 antibody cross-reacted with mHER2 and humanized HER2.

Fig.3 Detection of Her2 expression in Colon of WT C57BL/6 and hHER2 mice by FACS. (In cooperation with the third party)

Fig.4 Detection of Her2 expression in Skin of WT C57BL/6 and hHER2 mice by FACS. (In cooperation with the third party)

Fig.5 Detection of Her2 expression in kideny of WT C57BL/6 and hHER2 mice by FACS. (In cooperation with the third party)

Fig.6 In vivo efficacy assessment of Herceptin in hHER2 mice bearing B16F10-HER2 syngeneic tumor.

Body weight (A) and Tumor volume (B) were measured of hHER2 mice.