hCD20(2)

Nomenclature

C57BL/6Smoc-Ms4a1tm3(hCD20)Smoc

Cat. NO.

NM-HU-200114

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
Ms4a1

Synonyms

Cd20; Ly-44; Ms4a2; AA960661

NCBI ID

12482

MGI ID

88321

Ensembl ID

ENSMUSG00000024673

Pubmed

Ms4a1

Human Ortholog

MS4A1

Model Description

Extracellular and transmembrane region of the endogenous mouse Ms4a1 gene was replaced by corresponding region of human CD20 gene. While hCD20(Stock No.NM-HU-190068) mice function similarly to hCD20(2) mice,for more detailed information please contact our technical advisor.
Research Application：Immune-related; drug screening

Validation Data

71660ff7f7c1b6108cefd5fb18be7a1.png

Fig1. Detection of hCD20 expression on mCD19+ B cells in blood in hCD20 knockin mice.

NM-HU-200114-fig2.png

Fig2. Rituximab can bind to lymphocytes of hCD20 knockin mice.

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