hSIRPA(2)/hCD47

Nomenclature

C57BL/6Smoc-Sirpatm2(hSIRPA)Cd47tm1(hCD47)Smoc

Cat. NO.

NM-HU-2000111

Strain State

Repository Live

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Model Description

This SIRPA and CD47 double Knock-in strain is established by crossing hSIRPA and hCD47 mice together. These double double Knock-in mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.While hSIRPA/hCD47 (Stock No.NM-HU-190019) have been pulled from shelves for some reasons.
Research Application：Immunotherapy,cancer research,drug screening

Validation Data

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Fig 1. Detection of m&hCD47 expression on T, B, NK cells in HO hSIRPA(2)/hCD47 mice.

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Fig 2. Detection of m&hCD47 expression on erythrocytes and platelets in HO hSIRPA(2)/hCD47 mice.

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Fig 3. Detection of m&hCD47 expression in PB sample in HO hSIRPA(2)/hCD47 mice.

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Fig 4. Detection of m&hCD47 expression in spleen sample in HO hSIRPA(2)/hCD47 mice.

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