CAG-hACE2-IRES-Luc-Tg

Figure 1. Luciferase expression of the CAG-hACE2-IRES-Luciferase transgenic mice.

Figure 2. Western blot analysis of  ACE2  protein from the CAG-hACE2-IRES-Luciferase transgenic mice. 

Figure 3. Virus titers in the lungs of hACE2 Tg mice after SARS-CoV-2 infection. Groups of hACE2 Tg mice and wild type mice were inoculated with the same dose of SARS-CoV-2, the result shows that hACE2 Tg mice were highly susceptible to SARS-CoV-2 infection.

Figure 4. Body weight change in hACE2 Tg mice after drug treatment.

Figure 5. The viral load in the lung tissues of hACE2 Tg mice after drug treatment.