hAppNL-G-F

Nomenclature

C57BL/6Smoc-Apptm3(hAppNL-G-F)/Smoc

Cat. NO.

NM-HU-2000088

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
App

Synonyms

Ag; Abpp; Adap; Cvap; Abeta; betaApp; E030013M08Rik

Chromosome

16

NCBI ID

11820

MGI ID

88059

Ensembl ID

ENSMUSG00000022892

Pubmed

App

Human Ortholog

APP

Model Description

The endogenous mouse App gene was replaced by human AppNL-G-F.
Research Application：Alzheimer's disease research

Validation Data

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Fig1. Detection of APP expression in brain by RT-PCR.

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Fig2. (A) β-Amyloid (6E10) staining of WT and hAPPNL-G-F mice at 1, 3 and 6 months (magnification, 40x and 100x). (B) Statistics of 6E10 positive plaque area.

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Fig3. (A) Thioflavine S staining of WT and hAPPNL-G-F mice at 1, 3 and 6 months (magnification, 40x and 100x). (B) Statistics of ThiS positive plaque area.

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