hIL1RAP

Nomenclature

C57BL/6Smoc-Il1raptm3(hIL1RAP)Smoc

Cat. NO.

NM-HU-2000070

Strain State

Repository Live

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Gene Summary

Gene Symbol
Il1rap

Synonyms

AI255955; AV239853; IL-1RAcP; 6430709H04Rik

NCBI ID

16180

MGI ID

104975

Ensembl ID

ENSMUSG00000022514

Pubmed

Il1rap

Human Ortholog

IL1RAP

Model Description

The endogenous mouse Il1rap gene was replaced by human IL1RAP gene.
Research Application：Cytokine humanization model；drug screening

Validation Data

image.png

Fig.1 Detection of IL1RAP expression in liver by RT-PCR. 

Wild type: only one band at 266 bp with primers F1/R1(mIl1rap);

Homozygous: only one band at 566 bp with primers F2/R2(hIL1RAP).

Abbr. M, DNA marker; HO, homozygous; WT, wild type.image.png

Fig.2 Detection of hIL1RAP expressed in Bone Marrow in WT C57BL/6 and HO hIL1RAP mice.

image.png

Fig.3 Detection of hIL1RAP expressed in Peripheral Blood in WT C57BL/6 and HO hIL1RAP mice.

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Fig.4 Detection of hIL1RAP expressed in Spleen in WT C57BL/6 and HO hIL1RAP mice.


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