hIL33

Nomenclature

C57BL/6Smoc-Il33tm2(hIL33)/Smoc

Cat. NO.

NM-HU-2000069

Strain State

Embryo cryopreservation

Export PDF

Gene Summary

Gene Symbol
Il33

Model Description

The endogenous mouse Il33 gene was replaced by human IL33 gene.
Research Application:Cytokine humanization model;drug screening

Validation Data

image.png

Fig1. Detection of IL33 expression in lung by RT-PCR. Wild type: only one band at 287 bp with primers F1/R1(mIl33);Homozygous: only one band at 311 bp with primers F2/R2(hIL33); Abbr.. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.

image.png

Fig 2. Detection of hIL33 expression in lung homogenate by ELISA. Abbr. HO, homozygous; HE, heterozygous; WT, wild type.Note. hIL33 and C57BL/6 mice were i.p. injected with LPS(10mg/kg) for 4h.

image.png

Fig 3. Detection of mIL33 expression in lung homogenate by ELISA. Abbr. HO, homozygous; HE, heterozygous; WT, wild type. Note. hIL33 and C57BL/6 mice were i.p. injected with LPS(10mg/kg) for 4h.


You may also like

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

Learn more
Workshop:Progress and Advances in Preclinical immuno-Oncology Research

SMOC’s Annual Progress and Advances in Preclinical immuno-Oncology Research: The workshop is designed as a forum for ideas and opinions exchange on how to decrease the rate of clinical failures in oncology and immuno-oncology.

Learn more