hCD40(BALB/c)

Nomenclature

BALB/cAnSmoc-Cd40tm1(hCD40)/Smoc

Cat. NO.

NM-HU-2000047

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
CD40

Synonyms

IGM; p50; Bp50; GP39; IMD3; TRAP; HIGM1; T-BAM; Tnfrsf5; AI326936

NCBI ID

21939

MGI ID

88336

Ensembl ID

ENSMUSG00000017652

Pubmed

CD40

Human Ortholog

CD40

Model Description

The endogenous mouse Cd40 gene was replaced by human CD40 gene.
Research Application：Immunotherapy,drug screening

Validation Data

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Fig1. Analysis of hCD40 expression in PBMC in the hCD40 mice by FACS. hCD40 was expressed on B cells in PB.

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Fig2. Analysis of hCD40 expression on splenic B cells by FACS. hCD40 was expressed on the B cells in the spleen.

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Fig3. Analysis of human CD40 expression on splenic DCs and macrophages by FACS . The homozygous KI mouse expresses human CD40 on DCs and macrophages.（Provided by CrownBio）


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