hIL23A

Nomenclature

C57BL/6Smoc-Il23atm3(hIL23A)Smoc

Cat. NO.

NM-HU-18030

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
Il23a

Synonyms

p19 IL-23

NCBI ID

83430

MGI ID

1932410

Ensembl ID

ENSMUSG00000025383

Pubmed

Il23a

Human Ortholog

IL23A

Model Description

The endogenous mouse Il23a gene was replaced by humanIL23A gene .
Research Application：Immunotherapy,Cancer research,Drug screening

Validation Data

image.png

Fig1. Detection of hIL23 and mIL23 expression in serum by ELISA (n=2). 

Abbr. HO, homozygous; WT, wild type.

Note. hIL23A/hIL12B and C57BL/6 mice were i.p. injected with LPS.


image.png

Fig2. In vivo efficacy evaluation of anti-IL-23 in imiquimod (IMQ)-induced psoriasis model in hIL23A mice (In collaboration with the third party).

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